PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is an irreversible neurodegenerative disease mainly characterized by memory loss and cognitive decline. The etiology of AD is complex and remains incompletely understood. In recent years, genome-wide association studies (GWAS) have increasingly highlighted the central role of microglia in AD pathology. As a trans-membrane receptor specifically present on the microglia in the central nervous system, phosphatidylinositol-specific phospholipase C gamma 2 (PLCγ2) plays an important role in neuroinflammation. GWAS data and corresponding pathological research have explored the effects of PLCG2 variants on amyloid burden and tau pathologies that underline AD. The link between PLCγ2 and other AD-related effectors in human and mouse microglia has also been establishe

SUBMITTER: Li K 

PROVIDER: S-EPMC9485805 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature