Ethnicity-based classifications and medical genetics: One Health approaches from a Western Pacific perspective.

ABSTRACT: A new era presently dawns for medical genetics featuring individualised whole genome sequencing and promising personalised medical genetics. Accordingly, we direct readers attention to the continuing value of allele frequency data from Genome-Wide Association Surveys (GWAS) and single gene surveys in well-defined ethnic populations as a guide for best practice in diagnosis, therapy, and prescription. Supporting evidence is drawn from our experiences working with Austronesian volunteer subjects across the Western Pacific. In general, these studies show that their gene pool has been shaped by natural selection and become highly diverged from those of Europeans and Asians. These uniquely evolved patterns of genetic variation underlie contrasting schedules of disease incidence and drug respons

SUBMITTER: Edinur HA 

PROVIDER: S-EPMC9485872 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature