Expression patterns of serum MicroRNAs related to endothelial dysfunction in patients with subclinical hypothyroidism.

ABSTRACT:

Background

Increasing evidence has shown that elevated Thyroid stimulating hormone (TSH) levels are positively correlated with atherosclerosis (ATH) in patients with subclinical hypothyroidism (SCH). Some researchers found that the dysfunction of Endothelial Cells (ECs) in SCH plays an important role in the pathogenesis of ATH in SCH, but the association remains controversial.

Objectives

To determine the expression profiles of serum microRNAs critical to the function of Endothelial cells (ECs) may help reanalyze the possible mechanism underlying ATH in SCH and the association between ATH and SCH.

Methods

We used qRT-PCR to perform microRNA profiling and analysis in normal control subjects (NC), patients with SCH alone (SCH), patients with SCH and ATH (SCH+ATH), and pa

SUBMITTER: Yao X 

PROVIDER: S-EPMC9485940 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature