GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein.

ABSTRACT:

Background/objective

GLP-1R agonists have been shown to reduce fasting and postprandial plasma lipids, both of which are independent risk factors for the development of cardiovascular disease. However, how endogenous GLP-1 - which is rapidly degraded - modulates intestinal and hepatic lipid metabolism is less clear. A vagal gut-brain-axis originating in the portal vein has been proposed as a possible mechanism for GLP-1's anti-lipemic effects. Here we sought to examine the relationship between vagal GLP-1 signalling and intestinal lipid absorption and lipoprotein production.

Methods

Syrian golden hamsters or C57BL/6 mice received portal vein injections of GLP-1^(7-36), and postprandial and fasting plasma TG, TRL TG, or VLDL TG were examined. These experiments were

SUBMITTER: Hoffman S 

PROVIDER: S-EPMC9486018 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature