C-MAF coordinates enterocyte zonation and nutrient uptake transcriptional programs.

ABSTRACT: Small intestinal villi are structural and functional units present in higher vertebrates and uniquely adapted to nutrient absorption. Villus enterocytes are organized in transcriptional "zones" dedicated to specialized tasks such as absorption of specific nutrients. We report that the transcription factor c-MAF is expressed in differentiated lower and mid-villus enterocytes and is a target of BMP signaling. Maf inactivation perturbed the villus zonation program by increasing carbohydrate-related transcripts while suppressing transcripts linked to amino-acid and lipid absorption. The formation of cytoplasmic lipid droplets, shuttling dietary fat to chylomicrons, was impaired upon Maf loss indicating its role in dietary lipid handling. Maf inactivation under homeostatic conditions expanded t

SUBMITTER: Gonzalez-Loyola A 

PROVIDER: S-EPMC9486085 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature