Comprehensive multiomics analysis of cuproptosis-related gene characteristics in hepatocellular carcinoma.

ABSTRACT: Background: The mechanism of copper-induced cell death, which is called cuproptosis, has recently been clarified. However, the integrated role of cuproptosis-related genes in hepatocellular carcinoma (HCC) and its relationship with immune characteristics are still completely unknown. Methods: In this study, the expression, genetic, and transcriptional regulation states of 16 cuproptosis-related genes in HCC were systematically investigated. An unsupervised clustering method was used to identify distinct expression patterns in 370 HCC patients from the TCGA-HCC cohort. Differences in functional characteristics among different expression clusters were clarified by gene set variation analysis (GSVA). The abundances of immune cells in each HCC sample were calculated by the CIBERS

SUBMITTER: Fu J 

PROVIDER: S-EPMC9486098 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature