Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE ε4.

ABSTRACT: Cortical thinning has been described in many neurodegenerative diseases and used for both diagnosis and disease monitoring. The imaging signatures of post-stroke vascular cognitive impairment have not been well described. We investigated the trajectory of cortical thickness over 3 years following ischaemic stroke compared to healthy stroke-free age- and sex-matched controls. We also compared cortical thickness between cognitively normal and impaired stroke survivors, and between APOE ɛ4 carriers and non-carriers. T1-weighted MRI and cognitive data for 90 stroke survivors and 36 controls from the Cognition And Neocortical Volume After Stroke (CANVAS) study were used. Cortical thickness was estimated using FreeSurfer volumetric reconstruction according to the Desikan-Killiany parcellation at

SUBMITTER: Salah Khlif M 

PROVIDER: S-EPMC9486118 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature