Abnormal degree centrality values as a potential imaging biomarker for major depressive disorder: A resting-state functional magnetic resonance imaging study and support vector machine analysis.

ABSTRACT:

Objective

Previous studies have revealed abnormal degree centrality (DC) in the structural and functional networks in the brains of patients with major depressive disorder (MDD). There are no existing reports on the DC analysis method combined with the support vector machine (SVM) to distinguish patients with MDD from healthy controls (HCs). Here, the researchers elucidated the variations in DC values in brain regions of MDD patients and provided imaging bases for clinical diagnosis.

Methods

Patients with MDD (N = 198) and HCs (n = 234) were scanned using resting-state functional magnetic resonance imaging (rs-fMRI). DC and SVM were applied to analyze imaging data.

Results

Compared with HCs, MDD patients displayed elevated DC values in the vermis, left a

SUBMITTER: Lin H 

PROVIDER: S-EPMC9486164 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature