In silico design of refined ferritin-SARS-CoV-2 glyco-RBD nanoparticle vaccine.

ABSTRACT: With the onset of Coronavirus disease 2019 (COVID-19) pandemic, all attention was drawn to finding solutions to cure the coronavirus disease. Among all vaccination strategies, the nanoparticle vaccine has been shown to stimulate the immune system and provide optimal immunity to the virus in a single dose. Ferritin is a reliable self-assembled nanoparticle platform for vaccine production that has already been used in experimental studies. Furthermore, glycosylation plays a crucial role in the design of antibodies and vaccines and is an essential element in developing effective subunit vaccines. In this computational study, ferritin nanoparticles and glycosylation, which are two unique facets of vaccine design, were used to model improved nanoparticle vaccines for the first time. In this reg

SUBMITTER: Masoomi Nomandan SZ 

PROVIDER: S-EPMC9486171 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature