Glomerular disease classification and lesion identification by machine learning.

ABSTRACT:

Background

Classification of glomerular diseases and identification of glomerular lesions require careful morphological examination by experienced nephropathologists, which is labor-intensive, time-consuming, and prone to interobserver variability. In this regard, recent advance in machine learning-based image analysis is promising.

Methods

We combined Mask Region-based Convolutional Neural Networks (Mask R-CNN) with an additional classification step to build a glomerulus detection model using human kidney biopsy samples. A Long Short-Term Memory (LSTM) recurrent neural network was applied for glomerular disease classification, and another two-stage model using ResNeXt-101 was constructed for glomerular lesion identification in cases of lupus nephritis.

Results

The de

SUBMITTER: Yang CK 

PROVIDER: S-EPMC9486238 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature