Menopausal hormone therapy does not improve some domains of memory: A systematic review and meta-analysis.

ABSTRACT:

Background

Aged women appear to be at a higher risk of developing memory impairment than men. Whether menopausal hormone therapy (MHT) could improve memory in postmenopausal women remains unclear. We thus conducted a meta-analysis to investigate the potential effect of MHT on memory, especially verbal memory, in postmenopausal women.

Methods

PubMed, Cochrane, Embase, Chinese Biomedical Literature Database, and web of ClinicalTrials.gov were systematically searched for randomized controlled trials comparing MHT versus placebo in postmenopausal women. Our primary outcome of interest is memory function.

Results

We included 10 studies with 2,818 participants in the final analysis. There was no significant differences in immediate recall (weighted mean difference [WMD] 0.3

SUBMITTER: Chen L 

PROVIDER: S-EPMC9486389 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature