Metagenomic analysis reveals presence of different animal viruses in commercial fetal bovine serum and trypsin.

ABSTRACT: Animal-derived biological products, such as fetal bovine serum (FBS) and trypsin, are important supplements for scientific, pharmaceutical, and medical use. Although preventive guidelines and tests are implemented to reduce potential viral contamination in these biologicals, they do not target unusual or emerging viruses, leading to safety concerns. Using unbiased metagenomics, we investigated the presence of viruses in recently collected commercial FBS and trypsin samples from different geographic regions. In total, we detected viral sequences belonging to Parvoviridae, Anelloviridae, Flaviviridae, Herpesviridae, Caliciviridae, Nodaviridae, Rhabdoviridae, and Paramyxoviridae, including several viruses related to bovine diseases, viru

SUBMITTER: Zhang P 

PROVIDER: S-EPMC9486515 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature