Whole-genome resequencing reveals molecular imprints of anthropogenic and natural selection in wild and domesticated sheep.

ABSTRACT: The abundance of domesticated sheep varieties and phenotypes is largely the result of long-term natural and artificial selection. However, there is limited information regarding the genetic mechanisms underlying phenotypic variation induced by the domestication and improvement of sheep. In this study, to explore genomic diversity and selective regions at the genome level, we sequenced the genomes of 100 sheep across 10 breeds and combined these results with publicly available genomic data from 225 individuals, including improved breeds, Chinese indigenous breeds, African indigenous breeds, and their Asian mouflon ancestor. Based on population structure, the domesticated sheep formed a monophyletic group, while the Chinese indigenous sheep showed a clear geographical distribution trend. Com

SUBMITTER: Zhang DY 

PROVIDER: S-EPMC9486524 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature