Hyperactivation of the proteasome in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan.

ABSTRACT: Virtually all age-related neurodegenerative diseases (NDs) can be characterized by the accumulation of proteins inside and outside the cell that are thought to significantly contribute to disease pathogenesis. One of the cell's primary systems for the degradation of misfolded/damaged proteins is the ubiquitin proteasome system (UPS), and its impairment is implicated in essentially all NDs. Thus, upregulating this system to combat NDs has garnered a great deal of interest in recent years. Various animal models have focused on stimulating 26S activity and increasing 20S proteasome levels, but thus far, none have targeted intrinsic activation of the 20S proteasome itself. Therefore, we constructed an animal model that endogenously expresses a hyperactive, open gate proteasome in Caenorhabditi

SUBMITTER: Anderson RT 

PROVIDER: S-EPMC9486566 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature