DrDimont: explainable drug response prediction from differential analysis of multi-omics networks.

ABSTRACT:

Motivation

While it has been well established that drugs affect and help patients differently, personalized drug response predictions remain challenging. Solutions based on single omics measurements have been proposed, and networks provide means to incorporate molecular interactions into reasoning. However, how to integrate the wealth of information contained in multiple omics layers still poses a complex problem.

Results

We present DrDimont, Drug response prediction from Differential analysis of multi-omics networks. It allows for comparative conclusions between two conditions and translates them into differential drug response predictions. DrDimont focuses on molecular interactions. It establishes condition-specific networks from correlation within an omics layer that are

SUBMITTER: Hiort P 

PROVIDER: S-EPMC9486584 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature