Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating.

ABSTRACT:

Context

The neural regulation of appetite and energy homeostasis significantly overlaps with the neurobiology of stress. Frequent exposure to repeated acute stressors may cause increased allostatic load and subsequent dysregulation of the cortico-limbic striatal system leading to inefficient integration of postprandial homeostatic and hedonic signals. It is therefore important to understand the neural mechanisms by which stress generates alterations in appetite that may drive weight gain.

Objective

To determine glucocorticoid effects on metabolic, neural and behavioral factors that may underlie the association between glucocorticoids, appetite and obesity risk.

Methods

A randomized double-blind cross-over design of overnight infusion of hydrocortisone or saline follow

SUBMITTER: Bini J 

PROVIDER: S-EPMC9486604 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature