Negative Association of Smoking History With Clinically Manifest Cardiac Sarcoidosis: A Case-Control Study.

ABSTRACT:

Background

The etiology of sarcoidosis is still unknown and is likely related to a genetic susceptibility to unidentified environmental trigger(s). Our group and others have extensively described a specific phenotype of primarily Caucasian patients who have clinically manifest cardiac sarcoidosis (CS). In this study, we sought to explore whether smoking is associated with this specific phenotype of sarcoidosis.

Methods

We performed a case-control study. Cases with clinically manifest CS were prospectively enrolled in the Cardiac Sarcoidosis Multi-Center Prospective Cohort Study (CHASM-CS registry; NCT01477359) and answered a standardized smoking history questionnaire. Cases were matched 10:1 with controls from the Ontario Health Study. Pretreatment positron emission tomograp

SUBMITTER: Xu C 

PROVIDER: S-EPMC9486855 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature