Ontology highlight
ABSTRACT:
SUBMITTER: Shen S
PROVIDER: S-EPMC9486875 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Shen Siyuan S Jian Yanze Y Cai Zhaokui Z Li Fudong F Lv Mengqi M Liu Yongrui Y Wu Jihui J Fu Chuanhai C Shi Yunyu Y
Journal of molecular cell biology 20220901 5
In the fission yeast Schizosaccharomyces pombe, Mei2, an RNA-binding protein essential for entry into meiosis, regulates meiosis initiation. Mei2 binds to a specific non-coding RNA species, meiRNA, and accumulates at the sme2 gene locus, which encodes meiRNA. Previous research has shown that the Mei2 C-terminal RNA recognition motif (RRM3) physically interacts with the meiRNA 5' region in vitro and stimulates meiosis in vivo. However, the underlying mechanisms still remain elusive. We first empl ...[more]