Association of advanced paternal age with lung function at school age.

ABSTRACT:

Background

Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung function and fraction of exhaled nitric oxide (FeNO) in children.

Methods

We analyzed data from 1330 single-born children (576 girls, 43.3%; mean age, 6.4 years), who participated in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort and received measurements of lung function and FeNO at 6-year follow-up visits. Covariate-adjusted regression analyses were applied.

Results

Every 5-year increase in paternal age at birth was associated with 0.51% decrease in FEV₁/FVC ratio (95% CI - 0.86 to - 0.15; p = 0.0

SUBMITTER: Gau CC 

PROVIDER: S-EPMC9487029 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature