Ortho2align: a sensitive approach for searching for orthologues of novel lncRNAs.

ABSTRACT:

Background

Many novel long noncoding RNAs have been discovered in recent years due to advances in high-throughput sequencing experiments. Finding orthologues of these novel lncRNAs might facilitate clarification of their functional role in living organisms. However, lncRNAs exhibit low sequence conservation, so specific methods for enhancing the signal-to-noise ratio were developed. Nevertheless, current methods such as transcriptomes comparison approaches or searches for conserved secondary structures are not applicable to novel, previously unannotated lncRNAs by design.

Results

We present ortho2align-a versatile sensitive synteny-based lncRNA orthologue search tool with statistical assessment of sequence conservation. This tool allows control of the specificity of the sear

SUBMITTER: Mylarshchikov DE 

PROVIDER: S-EPMC9487038 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature