Understanding of black salve toxicity by multi-compound cytotoxicity assays.

ABSTRACT:

Background

Black salve is a controversial complementary and alternative medicine (CAM) associated with skin toxicity and skin cancer treatment failures. Black salve formulations vary between manufacturers and contain a number of botanical and synthetic constituents. The skin cancer cytotoxicity of a number of these constituents has not been assessed to date. The alkaloids from the rhizomes of Sanguinaria canadensis, a key black salve ingredient, have had their single compound cytotoxicity assessed; however, whether they possess synergistic cytotoxicity with other compounds has not been studied and is of direct clinical relevance. This research aimed to improve our understanding of the skin cancer cytotoxicity of black salve constituents.

Methods

The cytotoxicity of individua

SUBMITTER: Croaker A 

PROVIDER: S-EPMC9487053 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature