STMN1 as a novel prognostic biomarker in HCC correlating with immune infiltrates and methylation.

ABSTRACT:

Background

Upregulation of Stathmin 1 (STMN1), a cytoplasmic phosphoprotein that controls the dynamics of cellular microtubules, is linked to malignant behavior and poor prognosis in a range of malignancies. However, little research has been done on STMN1's potential role in HCC as a single factor in DNA methylation, m⁶A, or immunological modulation.

Results

STMN1 is overexpressed in hepatocellular carcinoma, where it is related to clinicopathological parameters and affects the prognosis of HCC patients. STMN1 overexpression plays an important role in the diagnosis and prognosis of hepatocellular carcinoma. Meanwhile, methylation of 7 CpG sites of STMN1 in HCC was correlated with prognosis, and STMN1 expression was closely related to m⁶A modification. I

SUBMITTER: Zhang ED 

PROVIDER: S-EPMC9487063 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature