Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer.
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ABSTRACT:
SUBMITTER: Palanca-Ballester C
PROVIDER: S-EPMC9487112 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer.
Palanca-Ballester Cora C Hervas David D Villalba Maria M Valdes-Sanchez Teresa T Garcia Diana D Alcoriza-Balaguer Maria Isabel MI Benet Marta M Martinez-Tomas Raquel R Briones-Gomez Andres A Galbis-Caravajal Jose J Calvo Alfonso A Juan Oscar O Lahoz Agustin A Cases Enrique E Sandoval Juan J
Clinical epigenetics 20220919 1
Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identified and validated an epigenetic 4-gene signature that yielded a high diagnostic performance in tissue and invasive pulmonary fluids. We analyzed DNA methylation levels using the ultrasensitive digital droplet PCR in noninvasive samples in a cohort of 83 patients. We demonstrated that BCAT1 ...[more]
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