DNA methylation underpins the epigenomic landscape regulating genome transcription in Arabidopsis.

ABSTRACT:

Background

It is challenging to determine the effect of DNA methylation on the epigenetic landscape and the function in higher organisms due to the lack of DNA methylation-free mutants.

Results

Here, the analysis of a recently generated Arabidopsis mutant completely devoid of DNA methylation reveals that DNA methylation underpins the genome-wide landscape of histone modifications. Complete loss of DNA methylation causes an upheaval of the histone modification landscape, including complete loss of H3K9me2 and widespread redistribution of active and H3K27me3 histone marks, mostly owing to the role of DNA methylation in initiating H3K9me2 deposition and excluding active marks and repressive mark H3K27me3; CG and non-CG methylation can act independently at some genomic regions w

SUBMITTER: Zhao L 

PROVIDER: S-EPMC9487137 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature