Assessing the environmental benefit of palladium-based single-atom heterogeneous catalysts for Sonogashira coupling.

ABSTRACT: The Pd-Cu catalysed Sonogashira coupling of terminal alkynes and aryl halides is a cornerstone synthetic strategy for C-C bond formation. Homogeneous organometallic systems conventionally applied are typically not reusable and require efficient downstream Pd removal steps for product purification, making it challenging to fully recover the precious metal. A holistic cradle-to-gate life cycle assessment (LCA) unveils that process footprint can be improved up to two orders of magnitude from repeated catalyst reuse. New classes of heterogeneous catalysts based on isolated metal atoms (single-atom catalysts, SACs) demonstrate promising potential to synergise the benefits of solid and molecular catalysts for efficient Pd utilisation. Here we show that using Pd atoms anchored on nitrogen-doped c

SUBMITTER: Faust Akl D 

PROVIDER: S-EPMC9487187 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature