Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling.

ABSTRACT:

Background

Arborinine is a natural product isolated from Globigerina parva (G. parva) leaf extract that shows strong anticancer activity with its role in clear-cell renal cell carcinoma (ccRCC) unreported.

Objective

We aim to evaluate the role of Arborinine in ccRCC.

Design

Arborinine was tested for its effects in ccRCC cell lines in vitro and in silico.

Results

Arborinine conferred inhibitory effect to ccRCC cells at reasonable doses. Arborinine showed inhibitory effects on Lysine Demethylase 1A (KDM1A) in ccRCC cells and decreased levels of KDM1A outputs and on epithelial mesenchymal transition (EMT) markers. Arborinine significantly inhibited proliferation, apoptosis, and cell cycle progression and migration of ccRCC cells. Using in silico</

SUBMITTER: Feng C 

PROVIDER: S-EPMC9487452 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature