FitDevo: accurate inference of single-cell developmental potential using sample-specific gene weight.

ABSTRACT: The quantification of developmental potential is critical for determining developmental stages and identifying essential molecular signatures in single-cell studies. Here, we present FitDevo, a novel method for inferring developmental potential using scRNA-seq data. The main idea of FitDevo is first to generate sample-specific gene weight (SSGW) and then infer developmental potential by calculating the correlation between SSGW and gene expression. SSGW is generated using a generalized linear model that combines sample-specific information and gene weight learned from a training dataset covering scRNA-seq data of 17 previously published datasets. We have rigorously validated FitDevo's effectiveness using a testing dataset with scRNA-seq data from 28 existing datasets and have also demonstra

SUBMITTER: Zhang F 

PROVIDER: S-EPMC9487676 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature