D-StructMAn: Containerized structural annotation on the scale from genetic variants to whole proteomes.

ABSTRACT:

Background

Structural annotation of genetic variants in the context of intermolecular interactions and protein stability can shed light onto mechanisms of disease-related phenotypes. Three-dimensional structures of related proteins in complexes with other proteins, nucleic acids, or ligands enrich such functional interpretation, since intermolecular interactions are well conserved in evolution.

Results

We present d-StructMAn, a novel computational method that enables structural annotation of local genetic variants, such as single-nucleotide variants and in-frame indels, and implements it in a highly efficient and user-friendly tool provided as a Docker container. Using d-StructMAn, we annotated several very large sets of human genetic variants, including all variants from Cl

SUBMITTER: Gress A 

PROVIDER: S-EPMC9487898 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature