Revisiting sex differences in the acquisition and extinction of threat conditioning in humans.

ABSTRACT: Findings pertaining to sex differences in the acquisition and extinction of threat conditioning, a paradigm widely used to study emotional homeostasis, remain inconsistent, particularly in humans. This inconsistency is likely due to multiple factors, one of which is sample size. Here, we pooled functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) data from multiple studies in healthy humans to examine sex differences during threat conditioning, extinction learning, and extinction memory recall. We observed increased functional activation in males, relative to females, in multiple parietal and frontal (medial and lateral) cortical regions during acquisition of threat conditioning and extinction learning. Females mainly exhibited higher amygdala activation during

SUBMITTER: Wen Z 

PROVIDER: S-EPMC9488021 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature