The neuroprotective effects of Lutongkeli in traumatic brain injury rats by anti-apoptosis mechanism.

ABSTRACT:

Purpose

To explore the neuroprotective effects of Lutongkeli (LTKL) in traumatic brain injury (TBI) and detect the related mechanism.

Methods

TBI model was established with LTKL administration (2 and 4 g/kg/d, p.o.). Motor function of rats was examined by Rotarod test. Nissl staining was used to show neuron morphology. Furthermore, the disease-medicine common targets were obtained with the network pharmacology and analyzed with Kyoto Encyclopedia of Genes and Genomes. Lastly, the predicted targets were validated by real-time polymerase chain reaction.

Results

After LTKL administration, neural behavior was significantly improved, and the number of spared neurons in brain was largely increased. Moreover, 68 bioactive compounds were identified, corresponding to 148 LTKL

SUBMITTER: Xiao QX 

PROVIDER: S-EPMC9488509 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature