Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis.

ABSTRACT: Pirfenidone is one of two approved therapies for the treatment of idiopathic pulmonary fibrosis (IPF). Randomised controlled clinical trials and subsequent post hoc analyses have demonstrated that pirfenidone reduces lung function decline, decreases mortality and improves progression-free survival. Long-term extension trials, registries and real-world studies have also shown similar treatment effects with pirfenidone. However, for patients with IPF to obtain the maximum benefits of pirfenidone treatment, the potential adverse events (AEs) associated with pirfenidone need to be managed. This review highlights the well-known and established safety profile of pirfenidone based on randomised controlled clinical trials and real-world data. Key strategies for preventing and managing the m

SUBMITTER: Lancaster LH 

PROVIDER: S-EPMC9488585 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature