Multi‑institutional development and validation of a nomogram to predict prognosis of early-onset gastric cancer patients.

ABSTRACT:

Background

Early-onset gastric cancer (EOGC, ≤45 years old) is characterized with increasing incidence and more malignant phenotypes compared with late-onset gastric cancer, which exhibits remarkable immune cell infiltration and is potential immunotherapeutic population. Till now, restricted survival information of EOGC is available due to limited case numbers. This study established a novel nomogram to help evaluate cancer-specific survival (CSS) of EOGC patients who underwent gastrectomy, and may provide evidence for predicting patients' survival.

Methods

We retrospectively enrolled a cohort containing 555 EOGC cases from five independent medical centers in China, among which 388 cases were randomly selected into a training set while the other 167 cases were assigned into

SUBMITTER: Liu H 

PROVIDER: S-EPMC9488636 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature