Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele.

ABSTRACT: Homozygous carriers of the deletion allele in the gene for angiotensin-converting enzyme (ACE-DD) demonstrate an elevated risk to develop inactivity-related type II diabetes and show an overshoot of blood glucose concentration with enduring exercise compared to insertion allele carriers. We hypothesized that ACE-DD genotypes exhibit a perturbed activity of signaling processes governing capillary-dependent glucose uptake in vastus lateralis muscle during exhaustive cycling exercise, which is associated with the aerobic fitness state. 27 healthy, male white Caucasian subjects (26.8 ± 1.1 years; BMI 23.6 +/- 0.6 kg m^-2) were characterized for their aerobic fitness based on a threshold of 50 ml O₂ min^-1 kg^-1 and the ACE-I/D genotype. Subjects complet

SUBMITTER: Fluck M 

PROVIDER: S-EPMC9488703 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature