Stronger implicit interference in cognitively healthy older participants with higher risk of Alzheimer's disease.

ABSTRACT:

Introduction

Abnormal cerebrospinal fluid amyloid beta (Aβ)₄₂ and tau levels have been revealed decades before symptoms onset in Alzheimer's disease (AD); however, the examination is usually invasive and inaccessible to most people. We thus aimed to develop a non-invasive behavioral test that targets early potential cognitive changes to gauge cognitive decline. Specifically, we hypothesized that older cognitive healthy participants would exhibit comparable performance when the task was explicit and relied on conscious cognition. However, when the task was implicit, the performance of participants at high and low risks for AD would bifurcate. That is, early changes in unconscious cognition could be linked to cognitive health.

Methods

We measured implicit interferen

SUBMITTER: Hung SM 

PROVIDER: S-EPMC9489163 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature