Exertional ventilation/carbon dioxide output relationship in COPD: from physiological mechanisms to clinical applications.

ABSTRACT: There is well established evidence that the minute ventilation (V'_E)/carbon dioxide output (V'_CO2 ) relationship is relevant to a number of patient-related outcomes in COPD. In most circumstances, an increased V'_E/V'_CO2 reflects an enlarged physiological dead space ("wasted" ventilation), although alveolar hyperventilation (largely due to increased chemosensitivity) may play an adjunct role, particularly in patients with coexistent cardiovascular disease. The V'_E/V'_CO2 nadir, in particular, has been found to be an important predictor of dyspnoea and poor exercise tolerance, even in patients with largely preserved forced expiratory volume in 1 s. As th

SUBMITTER: Neder JA 

PROVIDER: S-EPMC9489189 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature