The Long-Term Clinical and Economic Impact of Universal Varicella Vaccination in Slovenia.

ABSTRACT: Background: Despite the substantial burden of varicella infection, Slovenia does not currently have a universal varicella vaccination (UVV) program. We modeled the long-term clinical and economic impact of implementing 2-dose UVV strategies compared with no vaccination in Slovenia. Methods: A previously published dynamic transmission model was adapted to the demographics, varicella seroprevalence, herpes zoster incidence, and contact patterns in Slovenia. Six 2-dose UVV strategies, vs no vaccination, were considered over a 50-year period, including monovalent vaccination (Varivax^® [V-MSD] or Varilrix^® [V-GSK]) at ages 12 and 24 months, or monovalent vaccination at 15 months followed by monovalent or quadrivalent vaccination (ProQuad^® [MMRV-MSD

SUBMITTER: Burgess C 

PROVIDER: S-EPMC9489276 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature