Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging.

ABSTRACT: Platinum-based compounds are actively used in clinical trials as anticancer agents. In this study, two novel platinum complexes, (C1 = [PtCl₂(N(SO₂quin)dpa)], C2 = [PtCl₂(N(SO₂azobenz)dpa)]) containing quinoline and azobenzene appended dipicolylamine sulfonamide ligands were synthesized in good yield. The singlet attributable to methylene CH₂ protons of the ligands of C1 and C2 appears as two doublets in ¹H NMR spectra, which confirms the presence of magnetically nonequivalent protons upon coordination to platinum. Structural data of N(SO₂quin)dpa (L1), N(SO₂azobenz)dpa (L2) and PtCl₂(N(SO₂quin)dpa) confirmed the formation of the des

SUBMITTER: Maladeniya C 

PROVIDER: S-EPMC9489406 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature