Shared genetic architecture between type 2 diabetes and COVID-19 severity.

ABSTRACT:

Purpose

Patients with type 2 diabetes (T2D) have demonstrated a higher risk for developing more severe cases of COVID-19, but the complex genetic mechanism between them is still unknown. The aim of the present study was to untangle this relationship using genetically based approaches.

Methods

By leveraging large-scale genome-wide association study (GWAS) summary statistics of T2D and COVID-19 severity, linkage disequilibrium score regression and Mendelian randomization (MR) analyses were utilized to quantify the genetic correlations and causal relationships between the two traits. Gene-based association and enrichment analysis were further applied to identify putative functional pathways shared between T2D and COVID-19 severity.

Results

Significant, moderate genetic c

SUBMITTER: Ni J 

PROVIDER: S-EPMC9489484 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature