Lesion size and shape in central vein sign assessment for multiple sclerosis diagnosis: An in vivo and postmortem MRI study.

ABSTRACT:

Background

The "central vein sign" (CVS), a linear hypointensity on T2*-weighted imaging corresponding to a central vein/venule, is associated with multiple sclerosis (MS) lesions. The effect of lesion-size exclusion criteria on MS diagnostic accuracy has not been extensively studied.

Objective

Investigate the optimal lesion-size exclusion criteria for CVS use in MS diagnosis.

Methods

Cross-sectional study of 163 MS and 51 non-MS, and radiological/histopathological correlation of 5 MS and 1 control autopsy cases. The effects of lesion-size exclusion on MS diagnosis using the CVS, and intralesional vein detection on histopathology were evaluated.

Results

CVS+ lesions were larger compared to CVS- lesions, with effect modification by MS diagnosis (mean difference

SUBMITTER: Al-Louzi O 

PROVIDER: S-EPMC9489648 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature