Preterm Infant Fecal Microbiota and Metabolite Profiles Are Modulated in a Probiotic Specific Manner.

ABSTRACT:

Objectives

To compare the impact of two probiotic supplements on fecal microbiota and metabolites, as well as on gut inflammation in human milk-fed preterm infants.

Methods

In this single-center observational cohort study, we assessed the effects of Bifidobacterium longum subsp. infantis or Lactobacillus reuteri supplementation on the infant gut microbiota by 16S rRNA gene sequencing and fecal metabolome by 1 H nuclear magnetic resonance spectroscopy. Fecal calprotectin was measured as a marker of enteric inflammation. Aliquots of human or donor milk provided to each infant were also assessed to determine human milk oligosaccharide (HMO) content.

Results

As expected, each probiotic treatment was associated with increased proportions of the respective bacterial taxon.

SUBMITTER: Larke JA 

PROVIDER: S-EPMC9489674 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature