Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station.

ABSTRACT: Fluid interfaces significantly influence the dynamics of protein solutions, effects that can be isolated by performing experiments in microgravity, greatly reducing the amount of solid boundaries present, allowing air-liquid interfaces to become dominant. This investigation examined the effects of protein concentration on interfacial shear-induced fibrillization of insulin in microgravity within a containerless biochemical reactor, the ring-sheared drop (RSD), aboard the international space station (ISS). Human insulin was used as a model amyloidogenic protein for studying protein kinetics with applications to in situ pharmaceutical production, tissue engineering, and diseases such as Alzheimer's, Parkinson's, infectious prions, and type 2 diabetes. Experiments investigated three main stag

SUBMITTER: McMackin P 

PROVIDER: S-EPMC9489778 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature