Analysis of the role of m6A and lncRNAs in prognosis and immunotherapy of hepatocellular carcinoma.

ABSTRACT:

Objective

To study the role of m6A and lncRNAs in the prognosis and immunotherapy of hepatocellular carcinoma, construct the risk score of overall survival of hepatocellular carcinoma, and search for new therapeutic targets and drugs.

Methods

The data used in this study are obtained from The Cancer Genome Atlas (TCGA) database. A total of 424 HCC samples were included. The co-expression of lncRNAs and M6A-related genes in HCC was analyzed, COX regression analysis was conducted to construct the risk score for HCC prognosis, and the model's validity was further verified in different clinical trials subtypes and principal component analysis. GO enrichment analysis and immune function analysis were performed for the differential genes in the high-risk group and the low-risk grou

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9489786 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature