Selective sweep sites and SNP dense regions differentiate Mycobacterium bovis isolates across scales.

ABSTRACT: Mycobacterium bovis, a bacterial zoonotic pathogen responsible for the economically and agriculturally important livestock disease bovine tuberculosis (bTB), infects a broad mammalian host range worldwide. This characteristic has led to bidirectional transmission events between livestock and wildlife species as well as the formation of wildlife reservoirs, impacting the success of bTB control measures. Next Generation Sequencing (NGS) has transformed our ability to understand disease transmission events by tracking variant sites, however the genomic signatures related to host adaptation following spillover, alongside the role of other genomic factors in the M. bovis transmission process are understudied problems. We analyzed publicly available M. bovis datasets collect

SUBMITTER: Legall N 

PROVIDER: S-EPMC9489834 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature