Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder.

ABSTRACT: Substance use disorders are a debilitating group of psychiatric disorders with a high degree of comorbidity with major depressive disorder. Sleep and circadian rhythm disturbances are commonly reported in people with substance use disorder and major depression and associated with increased risk of relapse. Hippocampal somatostatin signaling is involved in encoding and consolidation of contextual memories which contribute to relapse in substance use disorder. Somatostatin and clock genes also have been implicated in depression, suggesting that these molecules may represent key converging pathways involved in contextual memory processing in substance use and major depression. We used hippocampal tissue from a cohort of subjects with substance use disorder (n = 20), subjects with major

SUBMITTER: Valeri J 

PROVIDER: S-EPMC9489843 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature