Altered dynamic functional connectivity of auditory cortex and medial geniculate nucleus in first-episode, drug-naive schizophrenia patients with and without auditory verbal hallucinations.

ABSTRACT:

Background and objective

As a key feature of schizophrenia, auditory verbal hallucination (AVH) is causing concern. Altered dynamic functional connectivity (dFC) patterns involving in auditory related regions were rarely reported in schizophrenia patients with AVH. The goal of this research was to find out the dFC abnormalities of auditory related regions in first-episode, drug-naïve schizophrenia patients with and without AVH using resting state functional magnetic resonance imaging (rs-fMRI).

Methods

A total of 107 schizophrenia patients with AVH, 85 schizophrenia patients without AVH (NAVH) underwent rs-fMRI examinations, and 104 healthy controls (HC) were matched. Seed-based dFC of the primary auditory cortex (Heschl's gyrus, HES), auditory association cortex (AAC, inclu

SUBMITTER: Xue K 

PROVIDER: S-EPMC9489854 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature