Integrated bioinformatics analysis reveals that EZH2-rich domains promote transcriptional repression in cervical cancer.

ABSTRACT: Cervical cancer is the third female cancer most common worldwide. The carcinogenic process involves an alteration of the mechanisms associated with transcription. Several studies have reported an oncogenic role of the polycomb complex subunit, EZH2. However, the role of EZH2 in cervical cancer is unknown. Hence, the objective of this study was to determine the role of EZH2 in transcriptional regulation in cervical cancer. The EZH2 expression and the methylation status of its promoter were analyzed in The Cancer Genome Atlas. The EZH2 enrichment profile was analyzed using chromatin immunoprecipitation with massively parallel DNA sequencing data provided by ENCODE project. The chromatin compartments were identified in the 4D Nucleome Data Portal. The functional annotation was examined in Enr

SUBMITTER: Salmeron-Barcenas EG 

PROVIDER: S-EPMC9489889 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature