Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile.

ABSTRACT:

Background

Several 9p21.3 variants, such as rs1333049, rs4977574, rs10757274, rs10757278, and rs10811661, identified from recent genome-wide association studies (GWASs) are reported to be associated with coronary artery disease (CAD) susceptibility but independent of dyslipidemia. This study investigated whether these 9p21.3 variants influenced lipid profiles.

Methods and results

By searching the PubMed and Cochrane databases, 101,099 individuals were included in the analysis. The consistent finding for the rs1333049 C allele on lipid profiles increased the triglyceride (TG) levels. Moreover, the rs4977574 G allele and the rs10757274 G allele, respectively, increased low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels. However,

SUBMITTER: Wei B 

PROVIDER: S-EPMC9489913 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature