Tumstatin (69-88) alleviates heart failure via attenuating oxidative stress in rats with myocardial infarction.

ABSTRACT:

Background

This study aimed to elucidate the effects of tumstatin (69-88) on heart failure and the underlying mechanism.

Materials and methods

Myocardial infarction (MI) was induced by ligating the left coronary artery in rats to trigger heart failure.

Results

Tumstatin (69-88) can reduce cardiac insufficiency in rats with heart failure. The increased cardiac fibrosis in MI rat was attenuated by tumstatin (69-88). Increase of cardiac atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in rats with myocardial infarction, and Ang II-treated NRCMs or H9C2 cells was inhibited by tumstatin (69-88). In the heart of MI rats, and Ang II-treated NRCMs or H9C2 cells, the superoxide anions and NADPH oxidase (Nox) activity rose and the superoxide dismutase (SOD)

SUBMITTER: Zhu C 

PROVIDER: S-EPMC9489976 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature