Economic evaluation of first-line nivolumab plus cabozantinib for advanced renal cell carcinoma in China.

ABSTRACT:

Background

In the Checkmate9ER trial, first-line treatment with nivolumab combined with cabozantinib (NI + CA) has shown efficacy for advanced renal cell carcinoma. This study aims to evaluate the impact of the health and economic outcomes of NI + CA in China.

Methods

Clinical efficacy data were derived from pivotal phase III CheckMate 9ER trial. A three-state partitioned survival model was established based on disease progression. Progression-free survival and overall survival of NI + CA vs. sunitinib were fitted with log-logistic and log-normal distributions, respectively. Mixture cure, non-mixture cure, and Royston/Parmar spline models were used to evaluate model robustness. The results derived the computational cost from the Chinese healthcare system perspective. The pri

SUBMITTER: Wang H 

PROVIDER: S-EPMC9490003 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature