Microarray analysis of lncRNA and mRNA expression profiles in patients with Legg-Calve-Perthes disease.

ABSTRACT:

Background

The etiology and underlying pathogenic mechanisms of Legg-Calve-Perthes disease (LCPD) still remain unclear. A disruption of blood supply to the femoral head, producing ischemic necrosis, appears to be the critical pathological event. The lncRNAs play crucial roles in many biological processes and are dysregulated in various human diseases. However, its expression profiles and the potential regulatory roles in the development of LCPD have not been investigated.

Methods

In this study, differentially expressed lncRNA and mRNA of Legg-Calve-Perthes disease patients were profiled. Several GO terms and pathways that play important roles in the regulation of vascular structure, function or coagulation were selected for further analysis. The lncRNA -mRNA interacting netw

SUBMITTER: Wang S 

PROVIDER: S-EPMC9490025 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature